Data Party THU

May 23, 2026 · Artificial Intelligence

ProteinOPD: Tsinghua’s Efficient Multi‑Objective Preference Alignment Framework for Protein Design

ProteinOPD introduces a multi‑teacher, on‑policy preference‑distillation framework that aligns protein language models with multiple design objectives—foldability, solubility and thermostability—while preserving generation quality, achieving up to 54% stability gains and an eight‑fold training speedup.