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Baidu Tech Salon
Baidu Tech Salon
May 20, 2024 · Artificial Intelligence

HelixFold-Multimer: High‑Performance Antigen‑Antibody and Peptide‑Protein Complex Structure Prediction

HelixFold‑Multimer, a new Baidu PaddleHelix model, outperforms AlphaFold 3 on antigen‑antibody and peptide‑protein complex predictions, achieving mean DockQ scores of 0.41 and 0.38 respectively and success rates up to 77 % when epitope data are used, and is already deployed in large‑molecule drug pipelines.

HelixFold-Multimerantibodybioinformatics
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HelixFold-Multimer: High‑Performance Antigen‑Antibody and Peptide‑Protein Complex Structure Prediction